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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Rattus norvegicus (Rat)
Gene	Chrm3
Synonym	M3R M3 receptor HM4 Chrm-3 cholinergic receptor, muscarinic 3, cardiac cholinergic receptor, muscarinic 3 cholinergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	P08483
Protein Data Bank	4daj, 4u14, 4u15, 4u16, 5zhp
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4daj.
BioLiP	BL0433837, BL0433838,BL0433839, BL0300355,BL0300356, BL0300353,BL0300354, BL0223908,BL0223909,BL0223910,, BL0300352
Therapeutic Target Database	N/A
ChEMBL	CHEMBL320
IUPHAR	15
DrugBank	N/A

Ligand

Name	tropicamide
Molecular formula	C17H20N2O2
IUPAC name	N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
Molecular weight	284.359
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.5
Synonyms	Q-201902 SMP1_000304 Spectrum4_000377 ST51015162 Tox21_110297_1 Tropicamide (JP15/USP/INN) Tropicamide Monohydrochloride, (R)-Isomer Tropicamide, (+-)-Isomer Tropikamid Paremyd HMS1568N17 HMS3267A13 508T754 I06-0811 AC-816 KBioGR_000873 AM84467 MCULE-4102613027 Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)- Mydriacyl BRD-A79672927-001-10-8 N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide Chauvin Brand of Tropicamide NCGC00016065-04 CTK4C6796 NCGC00024866-03 DSSTox_RID_80757 NSC757372 Prestwick0_000228 RP29909 SPBio_002196 SR-01000075351 Stulln Brand 2 of Tropicamide Tropicacyl Tropicamide Chauvin Brand Tropicamide Ocumed Brand Tropicamide, European Pharmacopoeia (EP) Reference Standard Ocu-Tropic HMS2092A18 HMS3712N17 AB00052120-10 KBio1_000448 ACN-036667 KS-5174 BBL028074 Minims tropicamide BGDKAVGWHJFAGW-UHFFFAOYSA-N Mydriaticum BSPBio_002289 N-Ethyl-N-(4-pyridylmethyl)tropamid CHEMBL1200604 NCGC00016065-07 NCGC00024866-06 EINECS 216-140-2 Prestwick3_000228 SBI-0051190.P003 Spectrum2_000936 SR-01000075351-5 TL8001101 Tropicamida [INN-Spanish] Tropicamide Minims Tropicamide [USAN:INN:BANJAN] Tropicamidum OcuTropic HMS3259M18 1508-75-4 Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)- AB0011259 KBio2_006200 AKOS005664076 LP01223 Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)- MolPort-000-159-321 BPBio1_000303 N-Ethyl-2-phenyl-N-4-[-pyridyl-methyl]hydracrylamide CAS_1508-75-4 NC00589 CPD000058523 NCGC00016065-11 DSSTox_CID_25220 Novartis Brand of Tropicamide FT-0657590 Rivex Brand of Tropicamide SMR000058523 Spectrum5_001585 STK934612 Tox21_501223 Tropicamide (JP17/USP/INN) Tropicamide Monohydrochloride, (S)-Isomer Tropicamide, (R)-Isomer Tropimil Pharmafair Brand of Tropicamide HMS1921I09 HMS3373B07 IDI1_000448 AC1L1KOZ KBioSS_001064 AN-15530 Medical Ophthalmics Brand of Tropicamide Benzeneacetamide,N-ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)- Mydriacyl (TN) BRN 0285563 N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide CHEBI:9757 NCGC00016065-05 D00397 NCGC00024866-04 DTXSID8045220 NSC_5593 Prestwick1_000228 s1913 Spectro-Cyl SR-01000075351-1 SW196691-3 Tropicamid Tropicamide Faure Tropicamide Pharmafair Brand Tropicamide, solid Ocumed Brand of Tropicamide HMS2095N17 (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide HMS501G10 AB00052120_11 KBio2_001064 AK164485 L001262 BCP13504 MLS001306442 Bistropamide Mydrum Cahill May Roberts Brand of Tropicamide N-Ethyl-N-(4-pyridylmethyl)tropamide Colircusi Tropicamida NCGC00016065-08 DB00809 NCGC00261908-01 Epitromina Prestwick_487 SCHEMBL23975 Spectrum3_000655 SR-01000075351-7 Tox21_110297 Tropicamide Monofree Tropicamide [USAN:USP:INN:BAN:JAN] Tropicamidum [INN-Latin] Opticyl GTPL7319 HMS3263F08 5-22-09-00359 (Beilstein Handbook Reference) I-Picamide AB2000370 KBio3_001509 Alcon Brand of Tropicamide LS-28545 Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)- Mydral BRD-A79672927-001-05-8 N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide # CCG-40076 NCGC00016065-03 CS-2362 NCGC00024866-02 DSSTox_GSID_45220 NSC-757372 Pharmakon1600-01500599 Ro 1-7683 SPBio_000872 Spectrum_000584 Stulln Brand 1 of Tropicamide Triaminic DM Tropicamide Alcon Brand Tropicamide Novartis Brand Tropicamide, (S)-Isomer Visumidriatic HMS2089M05 HMS3651K04 AB00052120 K-4793 AC1Q5IFA KS-00000H8Q API0004531 MFCD00058580 BG0349 Mydriafair BSPBio_000275 N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide NCGC00016065-06 D09PNY NCGC00024866-05 EBD22886 Ocu Tropic Prestwick2_000228 SAM002564235 SPECTRUM1500599 SR-01000075351-3 T 9778 Tropicamida Tropicamide for peak identification, European Pharmacopoeia (EP) Reference Standard Tropicamide Rivex Brand Tropicamide, United States Pharmacopeia (USP) Reference Standard Ocusoft Brand of Tropicamide HMS2235J15 HY-B0321 AB00052120_12 KBio2_003632 Akorn Brand of Tropicamide Lopac0_001223 BDBM82371 MLS002154240 Bournonville Brand of Tropicamide N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide CAS-1508-75-4 n-ethyl-n-(g-picolyl)tropamide component of Paremyd NCGC00016065-09 DivK1c_000448 NINDS_000448 EU-0101223 [ Show all ]
Inchi Key	BGDKAVGWHJFAGW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
PubChem CID	5593
ChEMBL	CHEMBL1200604
IUPHAR	N/A
BindingDB	82371
DrugBank	DB00809
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	38.02 nM	PMID2250662	BindingDB

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