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Name | Neurotensin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | NTSR2 |
Synonym | levocabastine-sensitive neurotensin receptor neurotensin receptor type 2 high-affinity levocabastine-sensitive neurotensin receptor NT2R NTR2 [ Show all ] |
Disease | N/A |
Length | 410 |
Amino acid sequence | METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT |
UniProt | O95665 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95665 |
3D structure model | This predicted structure model is from GPCR-EXP O95665. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2514 |
IUPHAR | 310 |
DrugBank | N/A |
Name | CHEMBL1766923 |
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Molecular formula | C35H57N9O8 |
IUPAC name | (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
Molecular weight | 731.896 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 9 |
XlogP | -3.0 |
Synonyms | BDBM50342246 H-Ala-Arg-Pro-Tyr-Ile-Leu-OH |
Inchi Key | GLOGZGJBCQXGGG-MDAZJAFHSA-N |
Inchi ID | InChI=1S/C35H57N9O8/c1-6-20(4)28(32(49)42-26(34(51)52)17-19(2)3)43-30(47)25(18-22-11-13-23(45)14-12-22)41-31(48)27-10-8-16-44(27)33(50)24(40-29(46)21(5)36)9-7-15-39-35(37)38/h11-14,19-21,24-28,45H,6-10,15-18,36H2,1-5H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)(H,51,52)(H4,37,38,39)/t20-,21-,24-,25-,26-,27-,28-/m0/s1 |
PubChem CID | 54585988 |
ChEMBL | CHEMBL1766923 |
IUPHAR | N/A |
BindingDB | 50342246 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 56.0 nM | PMID21446649 | BindingDB,ChEMBL |
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