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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL131690
Molecular formula	C25H27N3O
IUPAC name	3,3-diphenyl-1-[4-(pyridin-3-ylmethyl)piperazin-1-yl]propan-1-one
Molecular weight	385.511
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.3
Synonyms	1-[4-(3-Pyridinylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone AKOS028884920 3,3-Diphenyl-1-(4-pyridin-3-ylmethyl-piperazin-1-yl)-propan-1-one; hydrate BDBM50003488
Inchi Key	GJDOBZATTIEGBR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H27N3O/c29-25(28-16-14-27(15-17-28)20-21-8-7-13-26-19-21)18-24(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,19,24H,14-18,20H2
PubChem CID	10045642
ChEMBL	CHEMBL131690
IUPHAR	N/A
BindingDB	50003488
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	520.0 nM	PMID1433215	BindingDB,ChEMBL

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