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Name | Apelin receptor |
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Species | Homo sapiens (Human) |
Gene | APLNR |
Synonym | msr/apj GPCR34 G-protein coupled receptor HG11 G-protein coupled receptor APJ AGTRL1 [ Show all ] |
Disease | N/A |
Length | 380 |
Amino acid sequence | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD |
UniProt | P35414 |
Protein Data Bank | 5vbl |
GPCR-HGmod model | P35414 |
3D structure model | This structure is from PDB ID 5vbl. |
BioLiP | BL0380094, BL0380093 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1628481 |
IUPHAR | 36 |
DrugBank | N/A |
Name | MLS000389682 |
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Molecular formula | C18H15ClN4O3 |
IUPAC name | (4Z)-2-(4-chloro-3-nitrophenyl)-4-[[4-(dimethylamino)phenyl]methylidene]-1H-imidazol-5-one |
Molecular weight | 370.793 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 3.6 |
Synonyms | AC1M4NHX SMR000255956 (5Z)-2-(4-chloro-3-nitro-phenyl)-5-[4-(dimethylamino)benzylidene]-2-imidazolin-4-one 4-{[4-(dimethylamino)phenyl]methylene}-2-(4-chloro-3-nitrophenyl)-1,3-diazolin -5-one HMS2599P13 [ Show all ] |
Inchi Key | ABMXCSNRCQOXLG-DHDCSXOGSA-N |
Inchi ID | InChI=1S/C18H15ClN4O3/c1-22(2)13-6-3-11(4-7-13)9-15-18(24)21-17(20-15)12-5-8-14(19)16(10-12)23(25)26/h3-10H,1-2H3,(H,20,21,24)/b15-9- |
PubChem CID | 135433205 |
ChEMBL | CHEMBL1335315 |
IUPHAR | N/A |
BindingDB | 67259 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <40000.0 nM | N/A | BindingDB |
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