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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL1081793
Molecular formula	C22H25FN2O3S
IUPAC name	1-(1-ethylpiperidin-3-yl)-3-(3-fluorophenyl)sulfonyl-5-methoxyindole
Molecular weight	416.511
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.7
Synonyms	BDBM50313135 1-(1-ethylpiperidin-3-yl)-3-(3-fluorophenylsulfonyl)-5-methoxy-1H-indole
Inchi Key	ANKIDBINXHGJGY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25FN2O3S/c1-3-24-11-5-7-17(14-24)25-15-22(20-13-18(28-2)9-10-21(20)25)29(26,27)19-8-4-6-16(23)12-19/h4,6,8-10,12-13,15,17H,3,5,7,11,14H2,1-2H3
PubChem CID	46880531
ChEMBL	CHEMBL1081793
IUPHAR	N/A
BindingDB	50313135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	203.0 nM	PMID20138763	BindingDB,ChEMBL
Emax	50.0 %	PMID20138763	ChEMBL
Ki	16.0 nM	PMID20138763	BindingDB,ChEMBL

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