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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Bos taurus (Bovine)
Gene	PTGFR
Synonym	PGF receptor PGF2-alpha receptor Prostanoid FP receptor
Disease	N/A for non-human GPCRs
Length	362
Amino acid sequence	MSTNSSIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQKYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYKTDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKDSLKVAAISDLPVTEKVTQQTST
UniProt	P37289
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4820
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	15(S)-Latanoprost
Molecular formula	C26H40O5
IUPAC name	propan-2-yl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]hept-5-enoate
Molecular weight	432.601
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	4.3
Synonyms	145773-22-4 Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate AC1L1GXT propan-2-yl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]hept-5-enoate CTK7J6539 isopropyl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)cyclopentyl]hept-5-enoate AKOS030228257 TRA0064809 HMS3393H11 913258-34-1 KS-00000Z34 AN-601 trans Latanoprost [ Show all ]
Inchi Key	GGXICVAJURFBLW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3
PubChem CID	3890
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4200.0 nM	PMID9694973	PDSP

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