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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | CID 44433196 |
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Molecular formula | C17H18ClN5O2S2 |
IUPAC name | 6-chloro-5-(1-piperidin-3-ylpyrrolo[2,3-b]pyridin-3-yl)sulfonyl-7,7a-dihydroimidazo[2,1-b][1,3]thiazole |
Molecular weight | 423.934 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 2.3 |
Synonyms | N/A |
Inchi Key | AMYAFRNDXPYXNZ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H18ClN5O2S2/c18-14-16(22-7-8-26-17(22)21-14)27(24,25)13-10-23(11-3-1-5-19-9-11)15-12(13)4-2-6-20-15/h2,4,6-8,10-11,17,19,21H,1,3,5,9H2 |
PubChem CID | 44433196 |
ChEMBL | CHEMBL236104 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 66.0 nM | PMID17624788 | ChEMBL |
Emax | 47.0 % | PMID17624788 | ChEMBL |
Ki | 0.7 nM | PMID17624788 | ChEMBL |
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