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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	2-[4-(2-methoxyphenoxy)-3-nitrophenyl]quinoxaline
Molecular formula	C21H15N3O4
IUPAC name	2-[4-(2-methoxyphenoxy)-3-nitrophenyl]quinoxaline
Molecular weight	373.368
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.2
Synonyms	MCULE-6316908924 ST45066757 BDBM61785 Oprea1_024618 2-[4-(2-methoxyphenoxy)-3-nitro-phenyl]quinoxaline cid_1288612 SR-01000439244 AC1LPJTE MLS000672134 STK388831 Oprea1_050663 HMS2658L16 SR-01000439244-1 AKOS001619949 MolPort-000-745-832 ZINC1109954 1-(2-methoxyphenoxy)-2-nitro-4-quinoxalin-2-ylbenzene CHEMBL1534392 SMR000293571 [ Show all ]
Inchi Key	AMUIZQDUZFTYFV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15N3O4/c1-27-20-8-4-5-9-21(20)28-19-11-10-14(12-18(19)24(25)26)17-13-22-15-6-2-3-7-16(15)23-17/h2-13H,1H3
PubChem CID	1288612
ChEMBL	CHEMBL1534392
IUPHAR	N/A
BindingDB	61785
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<35430.0 nM	PubChem BioAssay data set	ChEMBL
EC50	35430.0 nM	N/A	BindingDB

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