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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	CHEMBL3104125
Molecular formula	C27H34FN5O2
IUPAC name	2-ethyl-N-[4-[4-[(3-ethyl-1,2,4-oxadiazol-5-yl)-phenylmethyl]piperazin-1-yl]-3-fluorophenyl]butanamide
Molecular weight	479.6
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.2
Synonyms	AMPRKYXQMPOVTC-UHFFFAOYSA-N 2-ethyl-N-(4-{4-[(3-ethyl-[1,2,4]-oxadiazol-5-yl)-phenyl-methyl]-piperazin-1-yl}-3-fluoro-phenyl)-butyramide BDBM50445657 SCHEMBL6115578
Inchi Key	AMPRKYXQMPOVTC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H34FN5O2/c1-4-19(5-2)26(34)29-21-12-13-23(22(28)18-21)32-14-16-33(17-15-32)25(20-10-8-7-9-11-20)27-30-24(6-3)31-35-27/h7-13,18-19,25H,4-6,14-17H2,1-3H3,(H,29,34)
PubChem CID	69670211
ChEMBL	CHEMBL3104125
IUPHAR	N/A
BindingDB	50445657
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	27.0 nM	PMID24365162	BindingDB,ChEMBL
pKb	7.45 -	PMID24365162	ChEMBL

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