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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	CHEMBL136684
Molecular formula	C19H20N4O2
IUPAC name	2-(3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxyquinazolin-4-amine
Molecular weight	336.395
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.1
Synonyms	SR-01000651481-1 2-(3,4-Dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinazolin-4-ylamine BDBM50073575 SR-01000651481 2-[3,4-Dihydroisoquinoline-2(1H)-yl]-6,7-dimethoxyquinazoline-4-amine
Inchi Key	AMHBGRVKWJLMMP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N4O2/c1-24-16-9-14-15(10-17(16)25-2)21-19(22-18(14)20)23-8-7-12-5-3-4-6-13(12)11-23/h3-6,9-10H,7-8,11H2,1-2H3,(H2,20,21,22)
PubChem CID	10664606
ChEMBL	CHEMBL136684
IUPHAR	N/A
BindingDB	50073575
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID9986714	BindingDB,ChEMBL

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