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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	N-Benzylquinazolin-4-amine
Molecular formula	C15H13N3
IUPAC name	N-benzylquinazolin-4-amine
Molecular weight	235.29
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.9
Synonyms	4-(Benzylamino)quinazoline BAS 01292565 HMS2233F15 ZINC109589 4-[(phenylmethyl)amino]quinazoline benzyl(quinazolin-4-yl)amine;hydrochloride cid_616573 MCULE-8562214870 SMR000526288 100818-54-0 AKOS000536814 BRD-K43796186-001-01-1 FVWANTDQRFSCAL-UHFFFAOYSA-N N-Benzyl-4-quinazolinamine # ST50008517 4-(Benzylamino)quinazoline deriv. 7 BCB03_000911 CHEMBL102726 HMS3373H15 Oprea1_089836 AB00481928-16 Benzyl-quinazolin-4-yl-amine D01WDI MLS000701321 SR-01000467951 AR-434/13153110 CHEBI:92768 HMS1379H04 N-benzyl-N-(4-quinazolinyl)amine Z57161635 4-Benzylaminoquinazoline BDBM3256 ChemDiv2_003678 IDI1_002393 SCHEMBL7612718 AC1LDDI3 benzylquinazolin-4-ylamine EiM17-05191 MolPort-001-960-903 SR-01000467951-1 [ Show all ]
Inchi Key	FVWANTDQRFSCAL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H13N3/c1-2-6-12(7-3-1)10-16-15-13-8-4-5-9-14(13)17-11-18-15/h1-9,11H,10H2,(H,16,17,18)
PubChem CID	616573
ChEMBL	CHEMBL102726
IUPHAR	N/A
BindingDB	3256
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1251.0 nM	N/A	BindingDB
IC50	2419.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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