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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL124382
Molecular formula	C19H20N2O
IUPAC name	[4-[2-(dimethylamino)ethyl]-1H-indol-2-yl]-phenylmethanone
Molecular weight	292.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.0
Synonyms	[4-(2-Dimethylamino-ethyl)-1H-indol-2-yl]-phenyl-methanone {4-[2-(dimethylamino)ethyl]-1h-indol-2-yl}(phenyl)methanone BDBM50106253 CTK6I0594
Inchi Key	AMEZLRKIJOOPNJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N2O/c1-21(2)12-11-14-9-6-10-17-16(14)13-18(20-17)19(22)15-7-4-3-5-8-15/h3-10,13,20H,11-12H2,1-2H3
PubChem CID	11833220
ChEMBL	CHEMBL124382
IUPHAR	N/A
BindingDB	50106253
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	260.0 nM	PMID11689074	BindingDB,ChEMBL

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