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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Adenosine receptor A3
Species	Homo sapiens (Human)
Gene	ADORA3
Synonym	ARA3 Adenosine receptor A3 A3AR A3 receptor TGPCR1
Disease	Cerebrovascular ischaemia Malaria Ischemia Inflammation Hepatocellular carcinoma; Hepatitis C virus infection Glaucoma Cancer [ Show all ]
Length	318
Amino acid sequence	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
UniProt	P0DMS8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T36059
ChEMBL	CHEMBL256
IUPHAR	21
DrugBank	BE0000354

Ligand

Name	2'-O-Methyladenosine
Molecular formula	C11H15N5O4
IUPAC name	(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
Molecular weight	281.272
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	-0.5
Synonyms	Adenosine, 2'-O-methyl- BDBM50144945 DTXSID50175671 SC-43502 0883AB 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol AKOS016003815 CHEMBL73237 K-6125 TC-152797 (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol 2'-O-Me-A 2'-O-METHYL-ADENOSINE AC1L2SDS AX8019363 CTK1A7124 PDSP1_001054 (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol 2-O-Methyladenosine AJ-45572 CHEBI:69426 FPUGCISOLXNPPC-IOSLPCCCSA-N SCHEMBL25936 (2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3-ol 140M796 AN-8216 cordysinin B MFCD00056002 UNII-02YX82IHZ5 (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-ol 2'-O-Me-Ado 2'-O-Methyl-D-adenosine AC1Q4Y1K BCP17411 DS-14586 PDSP2_001038 02YX82IHZ5 2140-79-6 AK-54699 HG1274 ST24033989 (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxy-tetrahydrofuran-3-ol 2''-O-Methyladenosine 2'-O-Methyl adenosine AC-8216 ANW-64052 CS-W012268 MolPort-009-198-191 ZINC3776540 (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxy-tetrahydrofuran-3-ol [ Show all ]
Inchi Key	FPUGCISOLXNPPC-IOSLPCCCSA-N
Inchi ID	InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
PubChem CID	102213
ChEMBL	CHEMBL73237
IUPHAR	N/A
BindingDB	50144945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID17560111	BindingDB,ChEMBL
IC50	15.0 nM	PMID17560111	BindingDB,ChEMBL
Imax	100.0 %	PMID17560111	ChEMBL

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