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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001179913
Molecular formula	C20H16N2O3
IUPAC name	2-(4-benzoylphenoxy)-N-pyridin-3-ylacetamide
Molecular weight	332.359
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.1
Synonyms	2-(4-benzoylphenoxy)-N-(3-pyridyl)acetamide BDBM97142 SMR000595433 SR-01000806163-3 2-[4-(phenylcarbonyl)phenoxy]-N-pyridin-3-yl-ethanamide cid_2534340 AC1M8BLS 2-(4-benzoylphenoxy)-N-(pyridin-3-yl)acetamide SR-01000806163 Z31790281 791127-70-3 HMS2904N24 2-(4-benzoylphenoxy)-N-(3-pyridinyl)acetamide AKOS034170900 MolPort-004-068-658 2-(4-benzoylphenoxy)-N-pyridin-3-ylacetamide CHEMBL1424583 SR-01000806163-2 ZINC12476500 MCULE-8571444495 [ Show all ]
Inchi Key	FNMUQXAXWHYNQS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H16N2O3/c23-19(22-17-7-4-12-21-13-17)14-25-18-10-8-16(9-11-18)20(24)15-5-2-1-3-6-15/h1-13H,14H2,(H,22,23)
PubChem CID	2534340
ChEMBL	CHEMBL1424583
IUPHAR	N/A
BindingDB	97142
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	399.11 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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