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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	(S)-zacopride
Molecular formula	C15H20ClN3O2
IUPAC name	4-amino-N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-2-methoxybenzamide
Molecular weight	309.794
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.7
Synonyms	ZINC3961 4-amino-N-[(8S)-1-azabicyclo[2.2.2]octan-8-yl]-5-chloro-2-methoxybenzamide NCGC00025295-01 BDBM50056419 SCHEMBL16233195 UNII-9GN3OT4156 component FEROPKNOYKURCJ-CYBMUJFWSA-N 4-Amino-N-(S)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxy-benzamide D0I4BZ PDSP1_001634 SCHEMBL5373467 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-((S)-methoxy)-benzamide ZACOPRIDE,R 4-amino-N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-2-methoxybenzamide GTPL2289 AC1O7H1O PDSP2_001618 Tocris-1795 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide CHEMBL28992 [ Show all ]
Inchi Key	FEROPKNOYKURCJ-CYBMUJFWSA-N
Inchi ID	InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m1/s1
PubChem CID	6604914
ChEMBL	CHEMBL28992
IUPHAR	N/A
BindingDB	50056419
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	0.9 -	Bioorg. Med. Chem. Lett., (1993) 3:6:1375	ChEMBL
EC50	55.9 nM	Bioorg. Med. Chem. Lett., (1996) 6:3:263	ChEMBL
EC50	56.0 nM	N/A	BindingDB
EC50	63.0 nM	N/A	BindingDB
EC50	63.1 nM	Bioorg. Med. Chem. Lett., (1993) 3:6:1375	ChEMBL
EC50	203.0 nM	, Bioorg. Med. Chem. Lett., (1992) 2:12:1613	BindingDB,ChEMBL
Ki	131.0 nM	, Bioorg. Med. Chem. Lett., (1996) 6:3:263	BindingDB,ChEMBL
Ki	383.0 nM	, PMID9046352, Bioorg. Med. Chem. Lett., (1995) 5:8:795	BindingDB,ChEMBL

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