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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	SMR000006308
Molecular formula	C17H26N4O4S
IUPAC name	[2-(tert-butylamino)-2-oxoethyl] 4-amino-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate
Molecular weight	382.479
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	2.8
Synonyms	4-Amino-3-cyclohexylcarbamoyl-isothiazole-5-carboxylic acid tert-butylcarbamoyl-methyl ester CHEMBL1392033 SR-01000328086-1 ZINC4889908 AC1LDDZ7 MLS000031973 BDBM97055 4-amino-3-[(cyclohexylamino)-oxomethyl]-5-isothiazolecarboxylic acid [2-(tert-butylamino)-2-oxoethyl] ester cid_646580 SR-01000328086-4 [2-(tert-butylamino)-2-oxidanylidene-ethyl] 4-azanyl-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate AKOS000804165 MLS000880747 4-amino-3-(cyclohexylcarbamoyl)isothiazole-5-carboxylic acid [2-(tert-butylamino)-2-keto-ethyl] ester SR-01000328086 HMS2379D21 SR-01000328086-5 [2-(tert-butylamino)-2-oxoethyl] 4-amino-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate ASN 06264474 regid844256 [ Show all ]
Inchi Key	FEQNTUXIYYKDDE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H26N4O4S/c1-17(2,3)20-11(22)9-25-16(24)14-12(18)13(21-26-14)15(23)19-10-7-5-4-6-8-10/h10H,4-9,18H2,1-3H3,(H,19,23)(H,20,22)
PubChem CID	646580
ChEMBL	CHEMBL1392033
IUPHAR	N/A
BindingDB	97055
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1955.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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