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GLASS

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GPCR

Name	Melanocortin receptor 4
Species	Homo sapiens (Human)
Gene	MC4R
Synonym	MC4-R MC4 receptor
Disease	Obesity; Sexual dysfunction Obesity; Diabetes Obesity Metabolic disorders Sexual dysfunction Sexual dysfunction; Obesity Female sexual dysfunction Erectile dysfunction Cachexia Anorexia nervosa cachexia [ Show all ]
Length	332
Amino acid sequence	MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProt	P32245
Protein Data Bank	N/A
GPCR-HGmod model	P32245
3D structure model	This predicted structure model is from GPCR-EXP P32245.
BioLiP	N/A
Therapeutic Target Database	T72458
ChEMBL	CHEMBL259
IUPHAR	285
DrugBank	N/A

Ligand

Name	MLS003124195
Molecular formula	C23H21FN4O
IUPAC name	N-[6-[4-(dimethylamino)phenyl]-3-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]acetamide
Molecular weight	388.446
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.5
Synonyms	SMR001292866 CHEMBL1873621
Inchi Key	AKHKMYWFQIREIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H21FN4O/c1-15(29)26-21-12-18(16-6-10-20(11-7-16)27(2)3)14-28-22(13-25-23(21)28)17-4-8-19(24)9-5-17/h4-14H,1-3H3,(H,26,29)
PubChem CID	49795091
ChEMBL	CHEMBL1873621
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<9912.0 nM	PubChem BioAssay data set	ChEMBL

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