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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000571626
Molecular formula	C13H16N4O3
IUPAC name	3-[4-(dimethylamino)-3-nitrophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Molecular weight	276.296
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.4
Synonyms	cid_2874826 SMR000193511 3-[4-(dimethylamino)-3-nitro-phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one AKOS016876795 MCULE-8272788161 6-[4-(dimethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone REGID_for_CID_2874826 AC1MFOCD F1638-0037 SMSF0009175 3-[4-(dimethylamino)-3-nitrophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one BDBM97080 6-[4-(dimethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydropyridazin-3(2H)-one CHEMBL1386646 SCHEMBL10333665 AKOS001012210 HMS2446P07 STK970331 6-(4-(dimethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one CB00743 MolPort-001-737-057 [ Show all ]
Inchi Key	FBZBPTAIJMWJJO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H16N4O3/c1-8-6-12(18)14-15-13(8)9-4-5-10(16(2)3)11(7-9)17(19)20/h4-5,7-8H,6H2,1-3H3,(H,14,18)
PubChem CID	2874826
ChEMBL	CHEMBL1386646
IUPHAR	N/A
BindingDB	97080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1723.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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