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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000664008
Molecular formula	C26H28N2O2S
IUPAC name	N-[2-methyl-4-(phenylsulfanylmethyl)phenyl]-4-(morpholin-4-ylmethyl)benzamide
Molecular weight	432.582
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.6
Synonyms	AC1LQBC9 SR-01000708930 ZINC19953736 N-[2-methyl-4-[(phenylthio)methyl]phenyl]-4-(4-morpholinylmethyl)benzamide HMS2583L13 N-{2-methyl-4-[(phenylthio)methyl]phenyl}-4-(4-morpholinylmethyl)benzamide AKOS003202664 MolPort-002-225-356 SR-01000708930-2 CHEMBL1425552 N-[2-methyl-4-[(phenylthio)methyl]phenyl]-4-(morpholinomethyl)benzamide MCULE-7590135530 SMR000270622 BDBM97089 N-[2-methyl-4-(phenylsulfanylmethyl)phenyl]-4-(morpholin-4-ylmethyl)benzamide STK915827 cid_1321677 N-{2-methyl-4-[(phenylsulfanyl)methyl]phenyl}-4-(morpholin-4-ylmethyl)benzamide [ Show all ]
Inchi Key	FBTMLLNWEFZLSO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H28N2O2S/c1-20-17-22(19-31-24-5-3-2-4-6-24)9-12-25(20)27-26(29)23-10-7-21(8-11-23)18-28-13-15-30-16-14-28/h2-12,17H,13-16,18-19H2,1H3,(H,27,29)
PubChem CID	1321677
ChEMBL	CHEMBL1425552
IUPHAR	N/A
BindingDB	97089
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	322.09 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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