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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Mus musculus (Mouse)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	513
Amino acid sequence	MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P32240
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2489
IUPHAR	343
DrugBank	N/A

Ligand

Name	Rivenprost
Molecular formula	C24H34O6S
IUPAC name	methyl 4-[2-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]butanoate
Molecular weight	450.59
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	1.8
Synonyms	Rivenprost [INN] 1WBO45T413 BDBM50318871 methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(e)-(3s)-3-hydroxy-4-(m-methoxymethylphenyl)1-butenyl]-5-oxocyclopentyl]-5-thiaheptanoate ONO-4819.CD ZINC3940680 4-[2-[(1R)-2beta-[(1E,3S)-3-Hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-3alpha-hydroxy-5-oxocyclopentane-1alpha-yl]ethylthio]butyric acid methyl ester D0O4XW ONO4819 AE1-734 methyl 4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3-(methoxymethyl)phenyl)but-1-enyl)-5-oxocyclopentyl)ethylthio)butanoate SCHEMBL2309978 256382-08-8 MolPort-027-640-849 ONO-4819CD 4-[[2-[(1R)-2beta-[(3S)-3-Hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-3alpha-hydroxy-5-oxocyclopentane-1alpha-yl]ethyl]thio]butanoic acid methyl ester GTPL1930 AKOS027326542 methyl 4-[2-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]butanoate UNII-1WBO45T413 4-(2-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-ethylsulfanyl)-butyric acid methyl ester CHEMBL303960 ONO-4819 ONO-AE1-734 Methyl 4-((2-((1R,2R,3R)-3-hydroxy-2-((1E,3S)-3-hydroxy-4-(3-(methoxymethyl)phenyl)but-1-en-1-yl)-5-oxocyclopentyl)ethyl)sulfanyl)butanoate [ Show all ]
Inchi Key	FBQUXLIJKPWCAO-AZIFJQEOSA-N
Inchi ID	InChI=1S/C24H34O6S/c1-29-16-18-6-3-5-17(13-18)14-19(25)8-9-20-21(23(27)15-22(20)26)10-12-31-11-4-7-24(28)30-2/h3,5-6,8-9,13,19-22,25-26H,4,7,10-12,14-16H2,1-2H3/b9-8+/t19-,20-,21-,22-/m1/s1
PubChem CID	9803828
ChEMBL	CHEMBL303960
IUPHAR	1930
BindingDB	50318871
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.6 nM	PMID20218623	BindingDB,ChEMBL
Ki	0.630957 nM	PMID11917107	IUPHAR

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