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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	Pyridaben
Molecular formula	C19H25ClN2OS
IUPAC name	2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one
Molecular weight	364.932
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	2-tert.-butyl-4-chloro-5-(4-tert.-butyl-benzylthio)-3(2H)-pyridazinone BAS 300 DTXSID5032573 HSDB 7052 MolPort-002-885-850 Pyramite SMR000550490 2-tert-Butyl-5-(4-tert-Butylbenzylthio)-4-chloropyridazin-3(2H)-one 2-tert-butyl-5-[(4-tert-butylbenzyl)thio]-4-chloropyridazin-3(2H)-one 3(2H)-Pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)- AC1L3MQJ C18614 CJ-24337 EC 405-700-3 KM3423 NCGC00164309-02 Pyridaben 100 microg/mL in Acetonitrile 2 -t-butyl-5-(p-t-butylbenzylthio)-4-chloro-3(2H)-pyridazinone SR-01000789284-3 ZINC1543237 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one 4-Chloro-2-(1,1-dimethylethyl)-5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-3(2H)-pyridazinone AKOS015897404 CC-34094 DSSTox_GSID_32573 GWN 1715 M865 NCI 129 Sanmite 2-tert-butyl-4-chloro-5-(4-tert-butylbenzyl)thio 3(2H)-pyridazinone 2-tert.-butyl-4-chloro-5-(4-tert.-butylbenzylthio)-3(2H)-pyridazinone 96489-71-3 BDBM58401 CHEMBL225963 DWFZBUWUXWZWKD-UHFFFAOYSA- InChI=1/C19H25ClN2OS/c1-18(2,3)14-9-7-13(8-10-14)12-24-15-11-21-22(19(4,5)6)17(23)16(15)20/h7-11H,12H2,1-6H3 NC 129 SR-01000789284 2-tert-Butyl-5-[(4-tert-butylbenzyl)sulfanyl]-4-chloro-3(2H)-pyridazinone # 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloranyl-pyridazin-3-one 3(2H)-Pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]- AC1Q6IRZ C19H25ClN2OS Damanlin FT-0082433 KS-1098 NCGC00164309-03 Pyridaben [ISO] 2-t-butyl-5-(p-t-butylbenzylthio)-4-chloro-3(2H)-pyridazinone Tox21_301090 2-tert-butyl-5-[(4-tert-butylphenyl)methylthio]-4-chloro-3-pyridazinone 489P713 AN-34810 CHEBI:38626 DSSTox_RID_78991 HMS2885L11 MLS001165698 Nexter SCHEMBL27429 2-tert-Butyl-5-(4-tert-butyl-benzylthio)-4-chloropyridazin-3(2H)-one 2E4JBA5272 AB0015419 C-20997 cid_91754 DWFZBUWUXWZWKD-UHFFFAOYSA-N J90047 NCGC00164309-01 Pyridaben 10 microg/mL in Cyclohexane SR-01000789284-2 2-tert-butyl-5-[(4-tert-butylbenzyl)thio]-4-chloro-pyridazin-3-one 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloro-pyridazin-3-one 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-3(2H)-pyridazinone ACT03255 CAS-96489-71-3 DSSTox_CID_12573 FT-0630993 LS-129791 NCGC00254990-01 Pyridaben, PESTANAL(R), analytical standard 2-tert-butyl-4-chloro-5-(4-tert-butylbenzyl) thio 3(2H)-pyridazinone UNII-2E4JBA5272 [ Show all ]
Inchi Key	DWFZBUWUXWZWKD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25ClN2OS/c1-18(2,3)14-9-7-13(8-10-14)12-24-15-11-21-22(19(4,5)6)17(23)16(15)20/h7-11H,12H2,1-6H3
PubChem CID	91754
ChEMBL	CHEMBL225963
IUPHAR	N/A
BindingDB	58401
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6.57 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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