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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL75029
Molecular formula	C19H21ClN2O3S
IUPAC name	2-[1-(4-chlorophenyl)sulfonyl-7-methoxyindol-3-yl]-N,N-dimethylethanamine
Molecular weight	392.898
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.1
Synonyms	{2-[1-(4-Chloro-benzenesulfonyl)-7-methoxy-1H-indol-3-yl]-ethyl}-dimethyl-amine BDBM50093049 N,N-Dimethyl-1-(4-chlorophenylsulfonyl)-7-methoxy-1H-indole-3-ethanamine
Inchi Key	AJHPZVCDJLLSRJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21ClN2O3S/c1-21(2)12-11-14-13-22(19-17(14)5-4-6-18(19)25-3)26(23,24)16-9-7-15(20)8-10-16/h4-10,13H,11-12H2,1-3H3
PubChem CID	12017574
ChEMBL	CHEMBL75029
IUPHAR	N/A
BindingDB	50093049
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	45.0 nM	PMID11055342	BindingDB,ChEMBL

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