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Name | P2Y purinoceptor 2 |
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Species | Homo sapiens (Human) |
Gene | P2RY2 |
Synonym | Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 [ Show all ] |
Disease | Dry eye disease Constipation Cystic fibrosis Lung cancer |
Length | 377 |
Amino acid sequence | MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL |
UniProt | P41231 |
Protein Data Bank | N/A |
GPCR-HGmod model | P41231 |
3D structure model | This predicted structure model is from GPCR-EXP P41231. |
BioLiP | N/A |
Therapeutic Target Database | T93515 |
ChEMBL | CHEMBL4398 |
IUPHAR | 324 |
DrugBank | BE0002401 |
Name | UTP-Gamma-S |
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Molecular formula | C9H15N2O14P3S |
IUPAC name | dihydroxyphosphinothioyl [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate |
Molecular weight | 500.2 |
Hydrogen bond acceptor | 15 |
Hydrogen bond donor | 7 |
XlogP | -4.1 |
Synonyms | (dihydroxyphosphinothioyloxy-hydroxyphosphoryl) [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate dihydroxyphosphinothioyl [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate AC1NSKQ9 CHEMBL220200 GTPL1735 [ Show all ] |
Inchi Key | DUDALCZPYHIGIR-XVFCMESISA-N |
Inchi ID | InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(23-8)3-22-26(16,17)24-27(18,19)25-28(20,21)29/h1-2,4,6-8,13-14H,3H2,(H,16,17)(H,18,19)(H,10,12,15)(H2,20,21,29)/t4-,6-,7-,8-/m1/s1 |
PubChem CID | 5311494 |
ChEMBL | CHEMBL220200 |
IUPHAR | 1735 |
BindingDB | 50205417 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 240.0 nM | PMID17302398 | BindingDB,ChEMBL |
EC50 | 1584.89 nM | PMID8564228 | IUPHAR |
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