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GLASS

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GPCR

Name	Alpha-1D adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1D
Synonym	alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R ADRA1A ADRA1 Adra-1 alpha 1D-adrenoceptor alpha 1D-adrenoreceptor alpha1D-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-adrenergic receptor 1a Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Alpha-1A adrenergic receptor alpha1D-AR [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction Fecal incontinence Glaucoma Hypertension Pediatric cancer Peripheral vascular disease Prostate disease Prostate hyperplasia [ Show all ]
Length	572
Amino acid sequence	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProt	P25100
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T53381
ChEMBL	CHEMBL223
IUPHAR	24
DrugBank	BE0004863, BE0000715

Ligand

Name	CHEMBL493283
Molecular formula	C26H29NO4
IUPAC name	N-[[(2R)-5,5-diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine
Molecular weight	419.521
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.0
Synonyms	BDBM50412786
Inchi Key	DSZAPUPSEUYRJU-HSZRJFAPSA-N
Inchi ID	InChI=1S/C26H29NO4/c1-28-24-14-8-9-15-25(24)29-17-16-27-18-23-19-31-26(20-30-23,21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,27H,16-20H2,1H3/t23-/m1/s1
PubChem CID	44568917
ChEMBL	CHEMBL493283
IUPHAR	N/A
BindingDB	50412786
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	102.33 nM	PMID18817363	BindingDB,ChEMBL

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