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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001174949
Molecular formula	C18H22N2O3
IUPAC name	2-[3-(3-methylbutoxy)phenoxy]-N-pyridin-4-ylacetamide
Molecular weight	314.385
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.4
Synonyms	2-[3-(3-methylbutoxy)phenoxy]-N-pyridin-4-yl-ethanamide CHEMBL1469379 Oprea1_374418 HMS1394F12 ZINC12512156 2-(3-isoamoxyphenoxy)-N-(4-pyridyl)acetamide BDBM65627 2-[3-(3-methylbutoxy)phenoxy]-N-pyridin-4-ylacetamide cid_2323706 SMR000592376 AC1M57V6 HMS2887M05 2-[3-(3-methylbutoxy)phenoxy]-N-(pyridin-4-yl)acetamide MolPort-003-994-563 303226-92-8 Enamine_000122 Z56765924 AKOS034451590 MCULE-2299229405 [ Show all ]
Inchi Key	DSDCOHBWUUJUSR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22N2O3/c1-14(2)8-11-22-16-4-3-5-17(12-16)23-13-18(21)20-15-6-9-19-10-7-15/h3-7,9-10,12,14H,8,11,13H2,1-2H3,(H,19,20,21)
PubChem CID	2323706
ChEMBL	CHEMBL1469379
IUPHAR	N/A
BindingDB	65627
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1058.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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