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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Homo sapiens (Human)
Gene	PTGER3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 Prostanoid EP3 receptor [ Show all ]
Disease	Pain Peripheral vascular disease Asthma Glaucoma
Length	390
Amino acid sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProt	P43115
Protein Data Bank	6m9t
GPCR-HGmod model	P43115
3D structure model	This structure is from PDB ID 6m9t.
BioLiP	BL0434681
Therapeutic Target Database	T85467
ChEMBL	CHEMBL3710
IUPHAR	342
DrugBank	BE0002375

Ligand

Name	CHEMBL427035
Molecular formula	C24H29NO4
IUPAC name	4-[3-[2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin-1-yl]propyl]benzoic acid
Molecular weight	395.499
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.7
Synonyms	4-{3-[2-(3-Hydroxy-4-phenyl-butyl)-5-oxo-pyrrolidin-yl]-propyl-}benzoic acid 4-(3-(2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin-1-yl)propyl)benzoic acid SCHEMBL4992115 4-{3-[2-(3-Hydroxy-4-phenyl-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-benzoic acid BDBM50181283 DQLDMXGXNPDHDY-UHFFFAOYSA-N [ Show all ]
Inchi Key	DQLDMXGXNPDHDY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H29NO4/c26-22(17-19-5-2-1-3-6-19)14-12-21-13-15-23(27)25(21)16-4-7-18-8-10-20(11-9-18)24(28)29/h1-3,5-6,8-11,21-22,26H,4,7,12-17H2,(H,28,29)
PubChem CID	11326896
ChEMBL	CHEMBL427035
IUPHAR	N/A
BindingDB	50181283
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<3200.0 nM	PMID16442794	BindingDB,ChEMBL

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