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Name | 5-hydroxytryptamine receptor 5A |
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Species | Homo sapiens (Human) |
Gene | HTR5A |
Synonym | 5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A [ Show all ] |
Disease | N/A |
Length | 357 |
Amino acid sequence | MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH |
UniProt | P47898 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47898 |
3D structure model | This predicted structure model is from GPCR-EXP P47898. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3426 |
IUPHAR | 10 |
DrugBank | BE0004688 |
Name | MLS000401592 |
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Molecular formula | C26H21FN4O5S2 |
IUPAC name | 1-(4-fluorophenyl)-N-[2-hydroxy-5-[(4-methoxyphenyl)sulfamoyl]phenyl]-3-methylthieno[2,3-c]pyrazole-5-carboxamide |
Molecular weight | 552.595 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 3 |
XlogP | 5.1 |
Synonyms | AC1MVXLJ SMR000243497 1-(4-fluorophenyl)-N-[2-hydroxy-5-[(4-methoxyphenyl)sulfamoyl]phenyl]-3-methyl-5-thieno[2,3-c]pyrazolecarboxamide HMS2536N23 1-(4-fluorophenyl)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-oxidanyl-phenyl]-3-methyl-thieno[2,3-c]pyrazole-5-carboxamide [ Show all ] |
Inchi Key | AIXCLGQVXMIORW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H21FN4O5S2/c1-15-21-14-24(37-26(21)31(29-15)18-7-3-16(27)4-8-18)25(33)28-22-13-20(11-12-23(22)32)38(34,35)30-17-5-9-19(36-2)10-6-17/h3-14,30,32H,1-2H3,(H,28,33) |
PubChem CID | 3690550 |
ChEMBL | CHEMBL1587837 |
IUPHAR | N/A |
BindingDB | 68066 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <92498.0 nM | PubChem BioAssay data set | ChEMBL |
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