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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001029145
Molecular formula	C29H38ClN7O
IUPAC name	N-[[1-[(4-chlorophenyl)methyl]piperidin-4-yl]methyl]-1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)piperidine-3-carboxamide
Molecular weight	536.121
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.3
Synonyms	N-[[1-(4-chlorobenzyl)-4-piperidyl]methyl]-1-(7,8,9,10-tetrahydro-6H-purin[9,8-a]azepin-4-yl)nipecotamide CHEMBL1523981 MCULE-9540854332 N-{[1-(4-chlorobenzyl)piperidin-4-yl]methyl}-1-(7,8,9,10-tetrahydro-6H-azepino[1,2-e]purin-4-yl)piperidine-3-carboxamide BDBM79035 N-[[1-[(4-chlorophenyl)methyl]-4-piperidinyl]methyl]-1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)-3-piperidinecarboxamide cid_20912355 MLS-0367695.0001 SMR000629112 AKOS001545206 MolPort-007-755-521 N-[[1-[(4-chlorophenyl)methyl]piperidin-4-yl]methyl]-1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)piperidine-3-carboxamide HMS2956A09 MLS-0367695.0002 AKOS021963057 [ Show all ]
Inchi Key	DLXQIDMLWQCEFE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H38ClN7O/c30-24-9-7-22(8-10-24)18-35-15-11-21(12-16-35)17-31-29(38)23-5-4-13-36(19-23)27-26-28(33-20-32-27)37-14-3-1-2-6-25(37)34-26/h7-10,20-21,23H,1-6,11-19H2,(H,31,38)
PubChem CID	20912355
ChEMBL	CHEMBL1523981
IUPHAR	N/A
BindingDB	79035
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29903.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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