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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000040609
Molecular formula	C17H20N4O
IUPAC name	9-methoxy-4-(3-methylpiperidin-1-yl)-5H-pyrimido[5,4-b]indole
Molecular weight	296.374
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	CHEMBL1300327 9-methoxy-4-(3-methyl-1-piperidinyl)-5H-pyrimido[5,4-b]indole MCULE-2689992902 BDBM97063 SMR000044316 9-methoxy-4-(3-methylpiperidin-1-yl)-5H-pyrimido[5,4-b]indole cid_663629 AC1LD9VU STL342795 844654-59-7 9-methoxy-4-(3-methylpiperidino)-5H-pyrimid[5,4-b]indole HMS2466J04 AKOS022120420 MolPort-002-608-747 [ Show all ]
Inchi Key	AIJBVQPEQXKJFG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H20N4O/c1-11-5-4-8-21(9-11)17-16-15(18-10-19-17)14-12(20-16)6-3-7-13(14)22-2/h3,6-7,10-11,20H,4-5,8-9H2,1-2H3
PubChem CID	663629
ChEMBL	CHEMBL1300327
IUPHAR	N/A
BindingDB	97063
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	399.9 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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