You can:
Name | 5-hydroxytryptamine receptor 1A |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Htr1a |
Synonym | 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 422 |
Amino acid sequence | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR |
UniProt | P19327 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL273 |
IUPHAR | 1 |
DrugBank | N/A |
Name | spiperone |
---|---|
Molecular formula | C23H26FN3O2 |
IUPAC name | 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 395.478 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 3.0 |
Synonyms | SR-01000000261-8 [3H]-spiperone NCGC00015964-02 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,8-triazaspiro[4.5]decan-4-one NCGC00015964-10 [ Show all ] |
Inchi Key | DKGZKTPJOSAWFA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) |
PubChem CID | 5265 |
ChEMBL | CHEMBL267930 |
IUPHAR | 99, 3300 |
BindingDB | 21397 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 123.0 nM | PMID3373482 | BindingDB |
IC50 | 123.03 nM | PMID3373482 | ChEMBL |
Ki | 25.12 nM | PMID8917649 | ChEMBL |
Ki | 30.0 nM | PMID2569041 | BindingDB,ChEMBL |
Ki | 40.0 nM | PMID3543362 | BindingDB,ChEMBL |
Ki | 49.0 nM | PMID8355253 | BindingDB,ChEMBL |
Ki | 58.0 nM | PMID9836624 | BindingDB,ChEMBL |
Ki | 114.81 nM | PMID8301575 | BindingDB |
Ki | 602.0 nM | PMID8230102 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417