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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Adenosine receptor A3
Species	Rattus norvegicus (Rat)
Gene	Adora3
Synonym	A3 receptor A3AR Adenosine receptor A3 ARA3 TGPCR1
Disease	N/A for non-human GPCRs
Length	320
Amino acid sequence	MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
UniProt	P28647
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3360
IUPHAR	21
DrugBank	N/A

Ligand

Name	CHEMBL610121
Molecular formula	C34H48N8O6S
IUPAC name	(2S,3S,4R)-5-[6-[10-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]decylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Molecular weight	696.868
Hydrogen bond acceptor	12
Hydrogen bond donor	5
XlogP	4.8
Synonyms	BDBM50366540
Inchi Key	DJXCSFITSMYHGG-YWVZPYGGSA-N
Inchi ID	InChI=1S/C34H48N8O6S/c1-4-35-33(45)30-28(43)29(44)34(48-30)42-22-39-27-31(37-21-38-32(27)42)36-19-11-9-7-5-6-8-10-12-20-40-49(46,47)26-18-14-15-23-24(26)16-13-17-25(23)41(2)3/h13-18,21-22,28-30,34,40,43-44H,4-12,19-20H2,1-3H3,(H,35,45)(H,36,37,38)/t28-,29+,30-,34?/m0/s1
PubChem CID	46875962
ChEMBL	CHEMBL610121
IUPHAR	N/A
BindingDB	50366540
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1100.0 nM	PMID9873707	BindingDB,ChEMBL

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