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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000730667
Molecular formula	C19H26ClN3O2
IUPAC name	2-(1-adamantyl)-4-chloro-5-(oxolan-2-ylmethylamino)pyridazin-3-one
Molecular weight	363.886
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.6
Synonyms	MCULE-1638368013 BDBM97105 SMR000308943 2-(1-adamantyl)-4-chloranyl-5-(oxolan-2-ylmethylamino)pyridazin-3-one cid_16193721 2-(1-adamantyl)-4-chloro-5-(tetrahydrofurfurylamino)pyridazin-3-one AKOS000481079 SR-01000124935 2-(1-adamantyl)-4-chloro-5-(2-oxolanylmethylamino)-3-pyridazinone HMS2770L07 2-(1-adamantyl)-4-chloro-5-[(tetrahydrofuran-2-ylmethyl)amino]pyridazin-3(2H)-one MolPort-004-882-256 AKOS022034467 CHEMBL1523593 SR-01000124935-1 2-(1-adamantyl)-4-chloro-5-(oxolan-2-ylmethylamino)pyridazin-3-one [ Show all ]
Inchi Key	AHXHATFSBJZLMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H26ClN3O2/c20-17-16(21-10-15-2-1-3-25-15)11-22-23(18(17)24)19-7-12-4-13(8-19)6-14(5-12)9-19/h11-15,21H,1-10H2
PubChem CID	16193721
ChEMBL	CHEMBL1523593
IUPHAR	N/A
BindingDB	97105
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29910.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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