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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	MLS000547944
Molecular formula	C19H21ClN4
IUPAC name	2-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-1-methylbenzimidazole
Molecular weight	340.855
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.5
Synonyms	2-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-1-methyl-benzimidazole ZINC19923764 2-{[4-(3-chlorophenyl)-1-piperazinyl]methyl}-1-methyl-1H-benzimidazole HMS2402B03 AQ-360/43173483 SCHEMBL4154137 2-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-1-methylbenzimidazole CHEMBL1440652 2-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1-methylbenzimidazole BDBM83296 SMR000115764 2-[[4-(3-chlorophenyl)piperazino]methyl]-1-methyl-benzimidazole cid_851992 AC1LGUE0 MolPort-002-847-894 [ Show all ]
Inchi Key	DGGCMRLNBJCGGO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21ClN4/c1-22-18-8-3-2-7-17(18)21-19(22)14-23-9-11-24(12-10-23)16-6-4-5-15(20)13-16/h2-8,13H,9-12,14H2,1H3
PubChem CID	851992
ChEMBL	CHEMBL1440652
IUPHAR	N/A
BindingDB	83296
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<92467.0 nM	PubChem BioAssay data set	ChEMBL

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