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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	733750-99-7
Molecular formula	C21H24FN7O5S
IUPAC name	N-(2-fluoro-4-methylsulfonylphenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
Molecular weight	505.525
Hydrogen bond acceptor	12
Hydrogen bond donor	1
XlogP	3.9
Synonyms	4-Pyrimidinamine, N-(2-fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-(1-methylethyl)-1,2,4-oxadiazol-5-yl)-1-piperidinyl)-5-nitro- AR-231,453 MolPort-019-939-259 AR231453, >=98% (HPLC) D0R5QF NCGC00386584-02 07Z1P4981I AOB87157 BDBM50244791 HY-15564 UNII-07Z1P4981I AR-231453 CHEMBL461384 N-(2-Fluoro-4-(methylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine (2-Fluoro-4-(methanesulfonyl)phenyl)(6-(4-(3-isopropyl-(1,2,4)oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yl)amine AJ-103813 AX8246104 DTXSID80223614 SCHEMBL114213 1399AC AR 231453 C21H24FN7O5S KB-145984 ZINC40861018 AR231453 CS-2475 N-(2-fluoro-4-methylsulfonylphenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl}-amine AKOS016011527 BCP08600 GTPL5653 SCHEMBL2734562 [ Show all ]
Inchi Key	DGBKNTVAKIFYNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
PubChem CID	24939268
ChEMBL	CHEMBL461384
IUPHAR	5653
BindingDB	50244791
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.65 nM	PMID21444206	BindingDB,ChEMBL
EC50	0.68 nM	PMID18698756	BindingDB,ChEMBL
EC50	6.30957 nM	PMID17289847	IUPHAR
EC50	700.0 nM	PMID27560285	BindingDB,ChEMBL
EC50	3000.0 nM	PMID24751443	BindingDB,ChEMBL
Efficacy	100.0 %	PMID24751443	ChEMBL
Intrinsic activity	102.0 %	PMID22264481	ChEMBL

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