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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL173304
Molecular formula	C26H29N5O4
IUPAC name	methyl 1-(dimethylcarbamoyl)-3-[6-(2-methylimidazo[4,5-c]pyridin-1-yl)hexanoyl]indole-4-carboxylate
Molecular weight	475.549
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.9
Synonyms	BDBM50062075 SCHEMBL7494285 1-Dimethylcarbamoyl-3-[6-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-hexanoyl]-1H-indole-4-carboxylic acid methyl ester
Inchi Key	DDMRMDXTWFXXQC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H29N5O4/c1-17-28-20-15-27-13-12-21(20)30(17)14-7-5-6-11-23(32)19-16-31(26(34)29(2)3)22-10-8-9-18(24(19)22)25(33)35-4/h8-10,12-13,15-16H,5-7,11,14H2,1-4H3
PubChem CID	10766924
ChEMBL	CHEMBL173304
IUPHAR	N/A
BindingDB	50062075
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	0.013 mg.kg-1	PMID9438024	ChEMBL
ED50	1.1 mg.kg-1	PMID9438024	ChEMBL

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