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GPCR

NamePutative P2Y purinoceptor 10
SpeciesHomo sapiens (Human)
GeneP2RY10
SynonymP2Y-like receptor
P2RY10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
[ Show all ]
DiseaseN/A
Length339
Amino acid sequenceMANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSKESGSSMIG
UniProtO00398
Protein Data BankN/A
GPCR-HGmod modelO00398
3D structure modelThis predicted structure model is from GPCR-EXP O00398.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562166
IUPHAR165
DrugBankN/A

Ligand

NameD0M2RI
Molecular formulaC36H58N6O14S
IUPAC name2-[(1R)-1-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]butanedioic acid
Molecular weight830.948
Hydrogen bond acceptor15
Hydrogen bond donor11
XlogP1.4
SynonymsAcAsp-Gla-Leu-Ile-Cha-Cys
Inchi KeySBWANKMZZMQXKQ-JHOOERKCSA-N
Inchi IDInChI=1S/C36H58N6O14S/c1-6-18(4)28(33(51)39-23(13-20-10-8-7-9-11-20)30(48)40-25(16-57)36(55)56)41-31(49)22(12-17(2)3)38-34(52)29(21(35(53)54)14-26(44)45)42-32(50)24(15-27(46)47)37-19(5)43/h17-18,20-25,28-29,57H,6-16H2,1-5H3,(H,37,43)(H,38,52)(H,39,51)(H,40,48)(H,41,49)(H,42,50)(H,44,45)(H,46,47)(H,53,54)(H,55,56)/t18?,21?,22-,23-,24-,25-,28-,29+/m0/s1
PubChem CID44305052
ChEMBLN/A
IUPHARN/A
BindingDB50096400
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501.3 nMPMID25970039BindingDB

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