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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuromedin-K receptor
Species	Homo sapiens (Human)
Gene	TACR3
Synonym	SP-N receptor Tac3r Nmkr NKR NK3 receptor NK-3R NK-3 receptor neuromedin K receptor neurokinin beta receptor Neurokinin B receptor Tachykinin receptor 3 [ Show all ]
Disease	Schizophrenia Schizophrenia; Schizoaffective disorders Psychotic disorders Psychiatric disorder Irritable bowel syndrome Depression Central nervous system disease Asthma [ Show all ]
Length	465
Amino acid sequence	MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
UniProt	P29371
Protein Data Bank	N/A
GPCR-HGmod model	P29371
3D structure model	This predicted structure model is from GPCR-EXP P29371.
BioLiP	N/A
Therapeutic Target Database	T29683
ChEMBL	CHEMBL4429
IUPHAR	362
DrugBank	BE0002371

Ligand

Name	CHEMBL221077
Molecular formula	C30H30N4O3
IUPAC name	methyl N-phenyl-N-[[2-phenyl-3-(piperidin-1-ylmethyl)quinoline-4-carbonyl]amino]carbamate
Molecular weight	494.595
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.5
Synonyms	BDBM50194569 N-phenyl-N''-(2-phenyl-3-piperidin-1-ylmethyl-quinoline-4-carbonyl)-hydrazinecarboxylic acid methyl ester
Inchi Key	AHIYAFPZNJJMMS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H30N4O3/c1-37-30(36)34(23-15-7-3-8-16-23)32-29(35)27-24-17-9-10-18-26(24)31-28(22-13-5-2-6-14-22)25(27)21-33-19-11-4-12-20-33/h2-3,5-10,13-18H,4,11-12,19-21H2,1H3,(H,32,35)
PubChem CID	44419059
ChEMBL	CHEMBL221077
IUPHAR	N/A
BindingDB	50194569
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	160.0 nM	PMID16950617	BindingDB,ChEMBL

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