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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000766664
Molecular formula	C14H11BrN4O5
IUPAC name	5-bromo-N-[(E)-(2-hydroxy-3-methoxy-5-nitrophenyl)methylideneamino]pyridine-3-carboxamide
Molecular weight	395.169
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	1.9
Synonyms	5-bromo-N''-[(E)-(5-methoxy-3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-3-pyridinecarbohydrazide AC1OA0NH SMR000414639 5-bromo-N'-[(5-methoxy-3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]pyridine-3-carbohydrazide 443977-12-6 5-Bromo-nicotinic acid [1-(2-hydroxy-3-methoxy-5-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 5-bromo-N''-[(E)-(5-methoxy-3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]pyridine-3-carbohydrazide AKOS005396826 STK102844 5-bromo-N'-[(E)-(2-hydroxy-3-methoxy-5-nitrophenyl)methylidene]pyridine-3-carbohydrazide CHEMBL1976677 5-bromanyl-N''-[(E)-(5-methoxy-3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]pyridine-3-carbohydrazide AC1NYSUN MolPort-000-780-503 5-bromo-N''-[(E)-(6-keto-5-methoxy-3-nitro-cyclohexa-2,4-dien-1-ylidene)methyl]nicotinohydrazide BDBM88946 5-bromo-N'-[(E)-(5-methoxy-3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]pyridine-3-carbohydrazide cid_5865017 [ Show all ]
Inchi Key	DJSNSDAGFGXYJR-UBKPWBPPSA-N
Inchi ID	InChI=1S/C14H11BrN4O5/c1-24-12-4-11(19(22)23)3-8(13(12)20)6-17-18-14(21)9-2-10(15)7-16-5-9/h2-7,20H,1H3,(H,18,21)/b17-6+
PubChem CID	135549844
ChEMBL	CHEMBL1976677
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<9970.0 nM	PubChem BioAssay data set	ChEMBL

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