Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	Tramazoline
Molecular formula	C13H17N3
IUPAC name	N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine
Molecular weight	215.3
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	2.0
Synonyms	SLE31693IV Tramazoline (INN) 1082-57-1 2-[(5,6,7,8-Tetrahydro-1-naphthyl)amino]-2-imidazoline BCP29020 DTXSID5046936 N-tetralin-5-yl-4,5-dihydro-1H-imidazol-2-amine Towk Tramazolinum [INN-Latin] 2-(5,6,7,8-tetrahydro-1-naphthylamino)-2-imidazoline 4,5-Dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-1H-imidazol-2-amine CHEBI:134893 Imidazolidine,2-[(5,6,7,8-tetrahydronaphthal-1-yl]imino- QQJLHRRUATVHED-UHFFFAOYSA-N SCHEMBL121944 Tramazolina [INN-Spanish] 2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine AC1Q4UQJ D0ZT8D N-(5,6,7,8-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazol-2-amine # STL483756 Tramazoline [INN:BAN] 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)- 2-[(5,6,7,8-tetrahydronaphthalen-1-yl)amino]-2-imidazoline BDBM50027056 EINECS 214-105-6 PDSP1_001098 TRAMAZOLIN UNII-SLE31693IV 2-(5,6,7,8-tetrahydro-1-naphthylimino)-imidazolidine CHEMBL32573 L000866 Rhinol SCHEMBL8623881 082T571 2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine tramazoline 2-(5,6,7,8-Tetrahydro-1-naphthylamino)-2-imidazoline 4,5-Dihydro- AN-48480 DB13064 N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine Tobispray Tramazolinum 2-(5,6,7, 8-tetrahydro-1-naphthylimino)-imidazolidine 3715-90-0 (mono-hydrochloride) BDBM50225288 Imidazolidin-2-ylidene-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine PDSP2_001082 Tramazolina ZINC1534528 (4,5-Dihydro-1H-imidazol-2-yl)-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine 2-(5,6,7,8-tetrahydronaphthalen-1-ylamino)-2-imidazoline AC1L1KJB D08624 Muconasal (TN) Rhynaspray [ Show all ]
Inchi Key	QQJLHRRUATVHED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)
PubChem CID	5524
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50027056
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	290.0 nM	PMID37098	BindingDB

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417