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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	6-Methoxy-1-phenyl-1H-benzimidazole
Molecular formula	C14H12N2O
IUPAC name	6-methoxy-1-phenylbenzimidazole
Molecular weight	224.263
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.1
Synonyms	6-Methoxy-1-phenyl-1H-benzoimidazole cid_652633 AKOS002783908 MLS000077152 1-phenyl-6-methoxybenzimid-azole CBMicro_030429 SMR000001075 6-methoxy-1-phenyl-1H-1,3-benzodiazole 6-methoxy-1-phenylbenzimidazole DBDPQMUWFPDEFP-UHFFFAOYSA-N BDBM3859 MolPort-000-279-681 1-Phenylbenzimidazole deriv. 76 CHEMBL356169 ZINC361259 AC1LCMN8 HMS2383F20 BIM-0030561.P001 SCHEMBL3063006 [ Show all ]
Inchi Key	DBDPQMUWFPDEFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H12N2O/c1-17-12-7-8-13-14(9-12)16(10-15-13)11-5-3-2-4-6-11/h2-10H,1H3
PubChem CID	652633
ChEMBL	N/A
IUPHAR	N/A
BindingDB	3859
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.00399 nM	N/A	BindingDB

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