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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	alpha-methyl-5-HT
Molecular formula	C11H14N2O
IUPAC name	3-(2-aminopropyl)-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.6
Synonyms	D09OYA NCGC00015629-04 SCHEMBL396996 AC1L1CXO Biomol-NT_000085 CCG-204907 L001159 NCGC00024651-03 alpha-M-5-HT CHEMBL275854 MB03476 PDSP2_001101 3-(2-aminopropyl)-1H-indol-5-ol alpha-Methylserotonin BPBio1_001083 FT-0645249 NCGC00015629-05 AKOS022643479 CHEBI:48295 Lopac0_000823 PDSP1_001117 alpha-Me-5-HT CTK6A6964 NCGC00015629-03 PDSP2_001662 BDBM50014945 BRD-A17745711-103-01-0 GTPL152 NCGC00024651-02 Alpha Methyl 5 Hydroxytryptamine LYPCGXKCQDYTFV-UHFFFAOYSA-N PDSP1_001679 [ Show all ]
Inchi Key	LYPCGXKCQDYTFV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3
PubChem CID	2107
ChEMBL	CHEMBL275854
IUPHAR	152
BindingDB	50014945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	251.189 - 2511.89 nM	PMID8813606, PMID9225293	IUPHAR

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