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GLASS

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GPCR

Name	D(4) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd4
Synonym	D(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4
Disease	N/A for non-human GPCRs
Length	387
Amino acid sequence	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProt	P30729
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3361
IUPHAR	217
DrugBank	N/A

Ligand

Name	630116-49-3
Molecular formula	C19H23N3O
IUPAC name	N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
Molecular weight	309.413
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.3
Synonyms	BDBM50200037 LS-193908 UNII-RWL9H93ARB A-412,997 D07VBS N-(3-methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide Dihydrochloride A412997 GTPL3301 RWL9H93ARB 2-(4-(pyridin-2-yl)piperidin-1-yl)-N-m-tolylacetamide N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide ZINC13984603 A-412997 DB-073239 NCGC00370711-04 1-Piperidineacetamide, N-(3-methylphenyl)-4-(2-pyridinyl)- AJ-64554 KB-270503 SCHEMBL4010266 2-(4-(Pyridin-2-yl)piperidin-1-yl)-N-m-tolylacetamide hcl CHEMBL375596 N-(3-methylphenyl)-4-(2-pyridinyl)-1-Piperidineacetamide a-412997 dihydrochloride DTXSID70212234 PubChem16924 2-(3'',4'',-5'',6''-tetrahydro-2''H-[2,4''-bipyridine]-1''-yl)-N-(m-tolyl)acetamide [ Show all ]
Inchi Key	JFCDMGGMCUKHST-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)
PubChem CID	10425450
ChEMBL	CHEMBL375596
IUPHAR	3301
BindingDB	50200037
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.9 nM	PMID16153699	IUPHAR

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