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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Mus musculus (Mouse)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT
UniProt	P97288
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2183
IUPHAR	9
DrugBank	N/A

Ligand

Name	SDZ-205557
Molecular formula	C14H21ClN2O3
IUPAC name	2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight	300.783
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.2
Synonyms	Benzoic acid, 4-amino-5-chloro-2-methoxy-, 2-(diethylamino)ethyl ester Lopac0_001153 NCGC00092301-03 BPBio1_000574 D0W8EP NCGC00015916-01 SCHEMBL1038983 2-(Diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate AC1L1JSU AKOS030238974 CCG-205227 L001009 NCGC00015916-05 SDZ 205557 2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester Benzoic acid,4-amino-5-chloro-2-methoxy-, 2-(diethylamino)ethyl ester CHEMBL287045 LS-186950 PDSP1_001668 ZINC1544798 4-Amino-5-chloro-2-methoxy-benzoic acid 2-diethylamino-ethyl ester BRD-K15868788-001-01-4 DTXSID90160102 NCGC00015916-03 Sdz 205,557 2-diethylaminoethyl 4-amino-5-chloro-2-methoxybenzoate AC1Q3LU5 BDBM50056401 CHEBI:92288 Lopac-S-174 NCGC00092301-02 SDZ-205-557 2-Methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester Biomol-NT_000157 CTK4C0686 LS-187597 PDSP2_001652 137196-67-9 ACMC-20cut4 BRD-K15868788-003-02-8 GTPL258 NCGC00015916-04 SDZ 205-557 2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]benzoate [ Show all ]
Inchi Key	FFNWMBDISAYHDC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
PubChem CID	5191
ChEMBL	CHEMBL287045
IUPHAR	258
BindingDB	50056401
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6.3 nM	PMID8867105, PMID8946946	BindingDB
Ki	7.76 nM	PMID8946946	BindingDB
Ki	7.94328 nM	PMID7498967	IUPHAR

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