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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Relaxin-3 receptor 1
Species	Homo sapiens (Human)
Gene	RXFP3
Synonym	GPCR135 RXFPR3 RXFP3 RLN3R1 RLN3 receptor 1 relaxin/insulin like family peptide receptor 3 G protein-coupled receptor SALPR Relaxin family peptide receptor 3 G-protein coupled receptor GPCR135 Somatostatin- and angiotensin-like peptide receptor [ Show all ]
Disease	N/A
Length	469
Amino acid sequence	MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
UniProt	Q9NSD7
Protein Data Bank	N/A
GPCR-HGmod model	Q9NSD7
3D structure model	This predicted structure model is from GPCR-EXP Q9NSD7.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628472
IUPHAR	353
DrugBank	N/A

Ligand

Name	135PAM1
Molecular formula	C27H21Cl2F6N3O2
IUPAC name	3-[3,5-bis(trifluoromethyl)phenyl]-1-[(3,4-dichlorophenyl)methyl]-1-[2-(5-methoxy-1H-indol-3-yl)ethyl]urea
Molecular weight	604.374
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	7.7
Synonyms	3-[3,5-bis(trifluoromethyl)phenyl]-1-[(3,4-dichlorophenyl)methyl]-1-[2-(5-methoxy-1H-indol-3-yl)ethyl]urea GTPL8343 3-[3,5-bis(trifluoromethyl)phenyl]-1-(3,4-dichlorobenzyl)-1-[2-(5-methoxy-1h-indol-3-yl)ethyl]urea D0CE5B
Inchi Key	FAXDMTURZKFXIY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H21Cl2F6N3O2/c1-40-20-3-5-24-21(12-20)16(13-36-24)6-7-38(14-15-2-4-22(28)23(29)8-15)25(39)37-19-10-17(26(30,31)32)9-18(11-19)27(33,34)35/h2-5,8-13,36H,6-7,14H2,1H3,(H,37,39)
PubChem CID	56953333
ChEMBL	N/A
IUPHAR	8343
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	758.578 nM	PMID22347403	IUPHAR

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