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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger2
Synonym	EP2 receptor PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProt	Q62928
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4909
IUPHAR	341
DrugBank	N/A

Ligand

Name	Doproston
Molecular formula	C20H34O4
IUPAC name	7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular weight	338.488
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.2
Synonyms	11-Deoxy-PGE1 AC1NR1FA GTPL1925 SR-01000946400 11-deoxyprostaglandin E1 CHEMBL3246389 LS-125856 UNII-UG6237D2HO 11-Deoxy PGE-1 7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid Doprostone Prost-13-en-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)- 11-deoxy-Prostaglandin E1 AKOS032429044 HMS3648B09 SR-01000946400-1 D0G5MT MolPort-002-528-276 ZINC4082710 11-deoxy Prostaglandin E1 9-oxo-15S-hydroxy-13E-prostaenoic acid FA(20:1(OH,Ke,cyclo)) SCHEMBL1056605 11-DeoxyPGE1 AY-23578 LMFA03010054 UG6237D2HO 37786-00-8 PDSP2_001670 [ Show all ]
Inchi Key	DPNOTBLPQOITGU-LDDQNKHRSA-N
Inchi ID	InChI=1S/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
PubChem CID	5283055
ChEMBL	N/A
IUPHAR	1925
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	31.6228 nM	PMID9537820	IUPHAR

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