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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	phytosphingosine 1-phosphate
Molecular formula	C18H40NO6P
IUPAC name	[(2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl] dihydrogen phosphate
Molecular weight	397.493
Hydrogen bond acceptor	7
Hydrogen bond donor	5
XlogP	1.3
Synonyms	CHEBI:46970 PhS1P (2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl dihydrogen phosphate D-ribo-Phytosphingosine-1-Phosphate phytosphingosine-1-phosphate 4-D-Hydroxysphinganine 1-Phosphate GTPL2922 [(2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl] dihydrogen phosphate CTK8F9378 phytoS1P D0L8NF SCHEMBL17522136 AKOS030242040 LMSP01050003 (2S,3S,4R)-2-Amino-1,3,4-octadecanetriol 1-(Dihydrogen Phosphate) d-ribo Phytosphingosine 1-Phosphate 38597-28-3 FT-0673893 ZINC64624517 [ Show all ]
Inchi Key	AYGOSKULTISFCW-KSZLIROESA-N
Inchi ID	InChI=1S/C18H40NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)18(21)16(19)15-25-26(22,23)24/h16-18,20-21H,2-15,19H2,1H3,(H2,22,23,24)/t16-,17+,18-/m0/s1
PubChem CID	10883829
ChEMBL	N/A
IUPHAR	2922
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.58489 nM	PMID12270137	IUPHAR

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