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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Chemokine-like receptor 1
Species	Homo sapiens (Human)
Gene	CMKLR1
Synonym	tazarotene induced gene 2 receptor RVER1 resolvin E1 receptor Gpcr27 G-protein coupled receptor DEZ G-protein coupled receptor ChemR23 CMKLR1 chemokine receptor-like 1 Chemerin1 chemerin receptor 1 TIG2 receptor [ Show all ]
Disease	N/A
Length	373
Amino acid sequence	MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
UniProt	Q99788
Protein Data Bank	N/A
GPCR-HGmod model	Q99788
3D structure model	This predicted structure model is from GPCR-EXP Q99788.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3540
IUPHAR	79
DrugBank	N/A

Ligand

Name	Resolvin E1
Molecular formula	C20H30O5
IUPAC name	(5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid
Molecular weight	350.455
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.4
Synonyms	552830-51-0 DB13105 RvE1 (5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-icosapentaenoic acid 6,8,10,14,16-Eicosapentaenoic acid, 5,12,18-trihydroxy-, (5S,6Z,8E,10E,12R,14Z,16E,18R)- GTPL3333 UNII-GND3JH08JA [3H]resolvin E1 (6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid D01IUB 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid FA(20:5(OH3)) RX-10001 ZINC56875015 (5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-Trihydroxy-6,8,10,14,16-eicosapentaenoic acid C18171 J2.218.407E [3H]RvE1 D0U1CY resolvinE1 (5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoic acid 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA GND3JH08JA SCHEMBL3321593 [(3)H]-labeled RvE1 (5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid CHEBI:81559 LMFA03140003 [ Show all ]
Inchi Key	AOPOCGPBAIARAV-OTBJXLELSA-N
Inchi ID	InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1
PubChem CID	10473088
ChEMBL	N/A
IUPHAR	3333
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	11.3 nM	PMID15753205, PMID20887750, PMID17339491	IUPHAR

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