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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	Dextropropoxyphene
Molecular formula	C22H29NO2
IUPAC name	[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate
Molecular weight	339.479
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.2
Synonyms	SCHEMBL25405 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate, (+)- [(2S,3R)-4-dimethylamino-3-methyl-1,2-di(phenyl)butan-2-yl] propanoate AC1L1UHN Antalvic C22H29NO2 Darvon (Salt/Mix) Dextropropoxifeno [INN-Spanish] Dextropropoxyphenum EINECS 207-420-5 propoxyphene (1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate (S)-alpha-(2-(Dimethylamino)-1-methylethyl)-alpha-phenylbenzeneethanol propanoate UNII-S2F83W92TK 3818-94-8 alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionoxybutane Benzeneethanol, .alpha.-[2-(dimethylamino)-1-methylethyl]-.alpha.-phenyl-, propanoate, [S-(R,S)]- CHEMBL1213351 DEA No. 9273 Dextropropoxyphene (INN) Dextroproxifeno [Spanish] GTPL7593 (+)-1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane Proxagesic Romidon (Salt/Mix) 1-Benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate, [S-(R,S)]- # ZINC1530769 alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat Bulk dextropropoxyphene (non-dosage forms) D0D4PB Destropropossifene [DCIT] Dextropropoxyphene [INN:BAN] Doloxene (Salt/Mix) Methanol, compd. with (+-)-alpha-(2-dimethylamino)-1-methylethyl-alpha- phenylphenethyl propionate (1:1) (+)-alpha-propoxyphene (2S,3R)-(+)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate(ester) SK 65 21086-94-2 Algafan BDBM82269 CAS_469-62-5 Dextropropoxyphen Dextropropoxyphenum [INN-Latin] Erantin (Salt/Mix) Propoxyphene, (+)- .alpha.-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate ester USAF EL-84 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate Benzeneethanol, alpha-((1R)-2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (alphaS)- d-Propoxyphene Depromic Dextropropoxyphene 0.1 mg/ml in Acetonitrile Dolene (Salt/Mix) HSDB 3175 (+)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate Proxyphen S2F83W92TK 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate (ester), (2S,3R)- [(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate Abalgin (Salt/Mix) alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat [German] C07406 Darvon Dextropropoxifeno Dextropropoxyphene[INN:BAN] DTXSID1023524 Propoxypene (+)-Propoxyphene solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material (D)-PROPOXYPHENE UNII-II2G62OV6F component XLMALTXPSGQGBX-GCJKJVERSA-N 2621-61-6 alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate ester Benzeneethanol, .alpha.-[2-(dimethylamino)-1-methylethyl]-.alpha.-phenyl-, propanoate (ester), [S-(R,S)]- CHEBI:51173 DB00647 Dextroproxifeno Femadol Propoxyphene-d Proxyvon .alpha.-d-Propoxyphene XLMALTXPSGQGBX-GCJKJVERSA-N 469-62-5 alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (S-(R,S))- D07809 Destropropossifene Dextropropoxyphene 1.0 mg/ml in Acetonitrile Doloxen (Salt/Mix) LS-46517 (+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionyloxybutane [ Show all ]
Inchi Key	XLMALTXPSGQGBX-GCJKJVERSA-N
Inchi ID	InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m1/s1
PubChem CID	10100
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82269
DrugBank	DB00647
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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