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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 2
Species	Homo sapiens (Human)
Gene	GABBR2
Synonym	HG20 GPRC3B GPR51 Gb2 gamma-aminobutyric acid (GABA) B receptor, 2 gamma-aminobutyric acid (GABA) B receptor 2 gamma-aminobutyric acid (GABA) B receptor GABABR2 GABAB2 GABA-BR2 GABA-B-R2 GABA-B R2 receptor G-protein coupled receptor 51 G protein-coupled receptor 51 GABA-B receptor 2 [ Show all ]
Disease	Pain Drug abuse Fragile X syndrome Nicotine dependence Partial seizures Depression Cancer Schizophrenia Absence seizures Anxiety disorder [ Show all ]
Length	941
Amino acid sequence	MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
UniProt	O75899
Protein Data Bank	4mr7, 4mr8
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mr7.
BioLiP	BL0264360, BL0264364, BL0264363, BL0264362, BL0264361
Therapeutic Target Database	T42446
ChEMBL	N/A
IUPHAR	N/A
DrugBank	BE0002340

Ligand

Name	Arbaclofen placarbil
Molecular formula	C19H26ClNO6
IUPAC name	(3R)-3-(4-chlorophenyl)-4-[[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]butanoic acid
Molecular weight	399.868
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.2
Synonyms	CHEMBL2107312 KB-81511 XP19986 847353-30-4 SCHEMBL351833 Arbaclofen placarbil [USAN:INN] FT-0686949 XP 19986 (3R)-3-(4-Chlorophenyl)-4-((((1S)-2-methyl-1-((2- methylpropanoyl)oxy)propoxy)carbonyl)amino)butanoic acid D08861 R-baclofen - XenoPort ZINC14209416 DB08892 UNII-W89H91R7VX Benzenepropanoic acid, 4-chloro-beta-(((((1S)-2-methyl-1-(2-methyl-1-oxopropoxy)propoxy)carbonyl)amino)methyl)-, (betaR)- JXTAALBWJQJLGN-KSSFIOAISA-N XP-19986 (3r)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid D0GX3L SB17500 Arbaclofen placarbil (USAN/INN) DTXSID40233754 W89H91R7VX [ Show all ]
Inchi Key	JXTAALBWJQJLGN-KSSFIOAISA-N
Inchi ID	InChI=1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1
PubChem CID	11281011
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB08892
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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