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GLASS

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 2
Species	Homo sapiens (Human)
Gene	GABBR2
Synonym	HG20 GPRC3B GPR51 Gb2 gamma-aminobutyric acid (GABA) B receptor, 2 gamma-aminobutyric acid (GABA) B receptor 2 gamma-aminobutyric acid (GABA) B receptor GABABR2 GABAB2 GABA-BR2 GABA-B-R2 GABA-B R2 receptor G-protein coupled receptor 51 G protein-coupled receptor 51 GABA-B receptor 2 [ Show all ]
Disease	Pain Drug abuse Fragile X syndrome Nicotine dependence Partial seizures Depression Cancer Schizophrenia Absence seizures Anxiety disorder [ Show all ]
Length	941
Amino acid sequence	MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
UniProt	O75899
Protein Data Bank	4mr7, 4mr8
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mr7.
BioLiP	BL0264360, BL0264364, BL0264363, BL0264362, BL0264361
Therapeutic Target Database	T42446
ChEMBL	N/A
IUPHAR	N/A
DrugBank	BE0002340

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
548259	4-aminobutyric acid	C4H9NO2	103.121	3 / 2	-3.2	Yes
549938	Arbaclofen placarbil	C19H26ClNO6	399.868	6 / 2	4.2	Yes
550091	(R)-Baclofen	C10H12ClNO2	213.661	3 / 2	-1.0	Yes
175256	baclofen	C10H12ClNO2	213.661	3 / 2	-1.0	Yes
550918	Cgp-36742	C7H18NO2P	179.2	3 / 2	-2.7	Yes
552085	gabapentin	C9H17NO2	171.24	3 / 2	-1.1	Yes

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